FLOW

$69.99

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An all-round cognitive enhancer is critical in the competitive world we live in today. In enhancing the mind, one must also attend to the physiological limitations of the body. Cognitive enhancement and mitochondrial optimization synergistically improve our mental and physical performance. FLOW is able to support this through its three-pronged synergistic approach: Cognitive Support, Neuronal Protection, and Mitochondrial Optimization, which bring together vital ingredients that compliment each other in enhancing the state your being.

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Description

Medicinal Ingredients
Medicinal Ingredients Per capsule Per 2 capsule(s) Per 4 capsule(s)
COGNITIVE ENHANCEMENT COMPLEX
Acetyl-L-Carnitine 125.00mg 250.00mg 500.00mg
Artichoke Ext. (5% Cynarin) 100.00mg 200.00mg 400.00mg
Alpha-GPC (Choline alfoscerate) 75.00mg 150.00mg 300.00mg
Cognigrape® Grape Ext.(9% Proanthocyanidins, 4% Malvidin-3-glucoside; 37:1) 62.50mg 125.00mg 250.00mg
Ginkgo biloba Ext. (24% Flavonoid glycosides, 6% Terpene lactones) 25.00mg 50.00mg 100.00mg
NEURONAL GUARD
Lion’s Mane Ext. (30% Polysaccharides; 4:1) 125.00mg 250.00mg 500.00mg
Gotu kola Ext. (10% Triterpenes; 20:1) 50.00mg 100.00mg 200.00mg
MITOCHONDRIAL OPTIMIZER
Bioenergy D-Ribose 100.00mg 200.00mg 400.00mg
Coenzyme Q10 25.00mg 50.00mg 100.00mg
PureQQ® Pyrroloquinoline quinone 5.00mg 10.00mg 20.00mg
ABSORPTION BOOST
Bioperine®Black Pepper Ext. (95% Piperine; 50:1) 3.00mg 6.00mg 12.00mg
Benefits
Cognitive Enhancement Complex

Acetyl-L-Carnitine

  1. Cross Blood-Brain Barrier1
  2. Boost neurotransmitter amount2
  3. Studied in Alzheimer’s patients to reduce cognitive decline, viable brain regeneration3,4
  4. Promote energy transport by improving fatty acid transport into mitochondria
  5. Improve glucose availability to brain5
  6. Increase noradrenaline and serotonin content5 

Alpha-GPC

  1. Boosts acetylcholine content in brain6,7
  2. Alzheimer’s patients – improve cognitive performance and both short term and long term memory8
  3. Impacts development of cerebral cortex (processing center of brain) – improve neuron communication and improve memory, motor function, information processing, mental focus, and learning8

Artichoke Extract

  1. Enhances long-term memory potentiation from cellular level9
  2. Impact cells involved in brain inflammation to reduce neural inflammation10

Cognigrape®,

  1. Patented Sicilian red grapes extract
  2. Studied using Mini-Mental State Examination (MMSE), Beck Depression Inventory (BDI), Hamilton Anxiety Rating Scale (HARS), and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)), with all significantly improved results11

Ginkgo biloba Extract

  1. Widely studied traditional Chinese medicine
  2. Improve blood circulation in brain12, synergistic with functions of other FLOW ingredients
  3. Large-scale studies validate improvements in information retention, attention, memory speed, reaction13, 14, 15

Neuronal Protection

Lion’s Mane Extract is a potent neuroprotector which stimulates the growth of Nerve Growth Factor16,

  1. Stimulate growth of Nerve Growth Factor16, promoting neuron growth and survival
  2. Human studies show significant reductions in cognitive decline, anxiety and depression symptoms17, 18

Gotu Kola Extract

  1. Known as the “student herb’ – mind sharpening effects
  2. Increases brain cell growth and boosts brain plasticity19
  3. Increases communication between neurons (dendrite and axon enhancement)20
  4. Prevent breakdown of acetylcholine, prolonging effects of neurotransmitters, enhancing memory21
  5. Shows increased longevity in elephant studies22

Mitochondrial Optimizer

PureQQ®

  1. Patented pyrroloquinoline quinone – once hailed as the newest vitamin
  2. Activates key proteins to increase mitochondrial biogenesis20, the energy factories in your cells
  3. Stimulate Nerve Growth Factor (by up to 40 times)21, promotes neuron protection
  4. Implicated as viable therapy for mitochondrial disorders, stress and sleep disorders, memory formation in more than 800 studies23, 24

Coenzyme Q10

  1. Key nutrient in mitochondria (energy production factory)
  2. Synergistic with PQQ to enhance the efficiency of ATP production in your cell’s mitochondria AND number of mitochondria23, 24

D-Ribose

  1. Naturally occurring monosaccharide (sugar) found in your cell’s mitochondria and essential for energy production25
  2. Multiple studies establish effectiveness for chronic fatigue syndrome, fibromyalgia26, 27 and superior to other sugars in its ability to enhance energy recovery and overall fitness28
  3. Provide “fuel” for your mitochondria to further enhance the other benefits of FLOW.

To top off all of this, Bioperine®, a clinically established novelty black pepper extract is used to enhance absorption of key ingredients in the intestines, to maximize the effects of these key ingredients, boosting you a whole new playing field.

References
  1. Liu, Jiankang, et al. “Comparison of the Effects of l-Carnitine and Acetyl-l-Carnitine on Carnitine Levels, Ambulatory Activity, and Oxidative Stress Biomarkers in the Brain of Old Rats.” Annals of the New York Academy of Sciences, vol. 1033, no. 1, 2004, pp. 117–131., doi:10.1196/annals.1320.011.
  2. White, Helen L., and Philip W. Scates. “Acetyl-l-Carnitine as a Precursor of Acetylcholine.” Neurochemical Research, vol. 15, no. 6, 1990, pp. 597–601., doi:10.1007/bf00973749.
  3. Spagnoli, A., et al. “Long-Term Acetyl-L-Carnitine Treatment in Alzheimer’s Disease.” Neurology, vol. 41, no. 11, 1991, pp. 1726–1726., doi:10.1212/wnl.41.11.1726.
  4. Kalaria, Rajesh N., and Sami I. Harik. “Carnitine Acetyltransferase Activity in the Human Brain and Its Microvessels Is Decreased in Alzheimer’s Disease.” Annals of Neurology, vol. 32, no. 4, 1992, pp. 583–586., doi:10.1002/ana.410320417.
  5. Smeland, Olav B., et al. “Chronic Acetyl-l-Carnitine Alters Brain Energy Metabolism and Increases Noradrenaline and Serotonin Content in Healthy Mice.” Neurochemistry International, vol. 61, no. 1, 2012, pp. 100–107., doi:10.1016/j.neuint.2012.04.008.
  6. Tomassoni, Daniele, et al. “Effects of Cholinergic Enhancing Drugs on Cholinergic Transporters in the Brain and Peripheral Blood Lymphocytes of Spontaneously Hypertensive Rats.” Current Alzheimer Research, vol. 9, no. 1, 2012, pp. 120–127., doi:10.2174/156720512799015118.
  7. Bronzetti, Elena, et al. “Effect of Ipsilateral Lesioning of the Nucleus Basalis Magnocellularis and of l-α-Glyceryl Phosphorylcholine Treatment on Choline Acetyltransferase and Acetylcholinesterase in the Rat Fronto-Parietal Cortex.” Neuroscience Letters, vol. 164, no. 1-2, 1993, pp. 47–50., doi:10.1016/0304-3940(93)90854-e.
  8. Moreno, M De Jesus Moreno. “Cognitive Improvement in Mild to Moderate Alzheimer’s Dementia after Treatment with the Acetylcholine Precursor Choline Alfoscerate: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial.” Clinical Therapeutics, vol. 25, no. 1, 2003, pp. 178–193., doi:10.1016/s0149-2918(03)90023-3.
  9. Bruno, O, et al. “GEBR-7b, a Novel PDE4D Selective Inhibitor That Improves Memory in Rodents at Non-Emetic Doses.” British Journal of Pharmacology, vol. 164, no. 8, 2011, pp. 2054–2063., doi:10.1111/j.1476-5381.2011.01524.x.
  10. Jang, S., et al. “Luteolin Reduces IL-6 Production in Microglia by Inhibiting JNK Phosphorylation and Activation of AP-1.” Proceedings of the National Academy of Sciences, vol. 105, no. 21, 2008, pp. 7534–7539., doi:10.1073/pnas.0802865105.
  11. Calapai, Gioacchino, et al. “A Randomized, Double-Blinded, Clinical Trial on Effects of a Vitis Vinifera Extract on Cognitive Function in Healthy Older Adults.” Frontiers in Pharmacology, vol. 8, 2017, doi:10.3389/fphar.2017.00776.
  12. Mashayekh, Ameneh, et al. “Effects of Ginkgo Biloba on Cerebral Blood Flow Assessed by Quantitative MR Perfusion Imaging: a Pilot Study.” Neuroradiology, vol. 53, no. 3, 2010, pp. 185–191., doi:10.1007/s00234-010-0790-6.
  13. Mix, Joseph A., and W. David Crews. “A Double-Blind, Placebo-Controlled, Randomized Trial OfGinkgo Bilobaextract EGb 761® in a Sample of Cognitively Intact Older Adults: Neuropsychological Findings.” Human Psychopharmacology: Clinical and Experimental, vol. 17, no. 6, 2002, pp. 267–277., doi:10.1002/hup.412.
  14. Kennedy, David O., et al. “The Dose-Dependent Cognitive Effects of Acute Administration of Ginkgo Biloba to Healthy Young Volunteers.” Psychopharmacology, vol. 151, no. 4, 2000, pp. 416–423., doi:10.1007/s002130000501.
  15. Cieza, Alarcos, et al. “Effects of Ginkgo Biloba on Mental Functioning in Healthy Volunteers.” Archives of Medical Research, vol. 34, no. 5, 2003, pp. 373–381., doi:10.1016/j.arcmed.2003.05.001.
  16. Lai, Puei-Lene, et al. “Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium Erinaceus (Higher Basidiomycetes) from Malaysia.” International Journal of Medicinal Mushrooms, vol. 15, no. 6, 2013, pp. 539–554., doi:10.1615/intjmedmushr.v15.i6.30.
  17. Mori, Koichiro, et al. “Improving Effects of the Mushroom Yamabushitake (Hericium Erinaceus) on Mild Cognitive Impairment: a Double-Blind Placebo-Controlled Clinical Trial.” Phytotherapy Research, vol. 23, no. 3, 2009, pp. 367–372., doi:10.1002/ptr.2634.
  18. Nagano, Mayumi, et al. “Reduction of Depression and Anxiety by 4 Weeks Hericium Erinaceus Intake.” Biomedical Research, vol. 31, no. 4, 2010, pp. 231–237., doi:10.2220/biomedres.31.231.
  19. Soumyanath, Amala, et al. “Centella Asiaticaaccelerates Nerve Regeneration upon Oral Administration and Contains Multiple Active Fractions Increasing Neurite Elongation in-Vitro.” Journal of Pharmacy and Pharmacology, vol. 57, no. 9, 2005, pp. 1221–1229., doi:10.1211/jpp.57.9.0018.
  20. Wanakhachornkrai, Oraphan, et al. “Neuritogenic Effect of Standardized Extract of Centella Asiatica ECa233 on Human Neuroblastoma Cells.” BMC Complementary and Alternative Medicine, vol. 13, no. 1, 2013, doi:10.1186/1472-6882-13-204.
  21. Wattanathorn, Jintanaporn, et al. “Positive Modulation of Cognition and Mood in the Healthy Elderly Volunteer Following the Administration of Centella Asiatica.” Journal of Ethnopharmacology, vol. 116, no. 2, 2008, pp. 325–332., doi:10.1016/j.jep.2007.11.038.
  22. Tsoukalas, Dimitris, et al. “Discovery of Potent Telomerase Activators: Unfolding New Therapeutic and Anti-Aging Perspectives.” Molecular Medicine Reports, 2019, doi:10.3892/mmr.2019.10614.
  23. Briones, Teresita L, and Hala Darwish. “Vitamin D Mitigates Age-Related Cognitive Decline through the Modulation of pro-Inflammatory State and Decrease in Amyloid Burden.” Journal of Neuroinflammation, vol. 9, no. 1, 2012, doi:10.1186/1742-2094-9-244.
  24. Harris, Calliandra B., et al. “Dietary Pyrroloquinoline Quinone (PQQ) Alters Indicators of Inflammation and Mitochondrial-Related Metabolism in Human Subjects.” The Journal of Nutritional Biochemistry, vol. 24, no. 12, 2013, pp. 2076–2084., doi:10.1016/j.jnutbio.2013.07.008.
  25. Nakano, Masahiko, et al. “Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep.” Functional Foods in Health and Disease, vol. 2, no. 8, 2012, p. 307., doi:10.31989/ffhd.v2i8.81.
  26. Itoh, Yuji, et al. “Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions.” Advances in Experimental Medicine and Biology Oxygen Transport to Tissue XXXVII, 2016, pp. 319–325., doi:10.1007/978-1-4939-3023-4_40.
  27. Ben-Meir, Assaf, et al. “Coenzyme Q10 Restores Oocyte Mitochondrial Function and Fertility during Reproductive Aging.” Aging Cell, vol. 14, no. 5, 2015, pp. 887–895., doi:10.1111/acel.12368.
  28. Duberley, K.e., et al. “Effect of Coenzyme Q10 Supplementation on Mitochondrial Electron Transport Chain Activity and Mitochondrial Oxidative Stress in Coenzyme Q10 Deficient Human Neuronal Cells.” The International Journal of Biochemistry & Cell Biology, vol. 50, 2014, pp. 60–63., doi:10.1016/j.biocel.2014.02.003.
  29. Mahoney, Diane E., et al. “Understanding D-Ribose and Mitochondrial Function.” Advances in Bioscience and Clinical Medicine, vol. 6, no. 1, 2018, p. 1., doi:10.7575/aiac.abcmed.v.6n.1p.1.
  30. Teitelbaum, Jacob E., et al. “The Use of D-Ribose in Chronic Fatigue Syndrome and Fibromyalgia: A Pilot Study.” The Journal of Alternative and Complementary Medicine, vol. 12, no. 9, 2006, pp. 857–862., doi:10.1089/acm.2006.12.857.
  31. Teitelbaum, Jacob. “Treatment of Chronic Fatigue Syndrome and Fibromyalgia with D-Ribose– An Open-Label, Multicenter Study.” The Open Pain Journal, vol. 5, no. 1, 2012, pp. 32–37., doi:10.2174/1876386301205010032.
  32. Seifert, John G., et al. “The Influence of D-Ribose Ingestion and Fitness Level on Performance and Recovery.” Journal of the International Society of Sports Nutrition, vol. 14, no. 1, 2017, doi:10.1186/s12970-017-0205-8.
Test Results
Assessment Criteria Test Test Method Specification Test Result
Identity Shape & Color Organoleptic
Performance Tests Disintegration USP <2040> ≤ 30 min @ 37°C & pH 4.5
Average Weight USP <2091> mg ± 10%
Weight Variation USP <2091> As Per USP
Purity/ Microbial contaminants Total Aerobic Count USP <2021> < 1 X 103 CFU/g
Total Combined Yeast and Mold USP <2021> < 1 X 102 CFU/g
Escherichia coli USP <2022> Absent
Salmonella spp. USP <2022> Absent
Staphylococcus aureus USP <2022> Absent
Heavy Metals Arsenic EPA/ICP/MS < 1.0ppm
Cadmium EPA/ICP/MS < 1.0ppm
Lead EPA/ICP/MS < 1.0ppm
Total Mercury EPA/ICP/MS < 1.0ppm

Additional information

Weight .1112 kg
Dimensions 6 × 6 × 12 cm