PROLIVERATE

$5.00 $45.00

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“I feel sorry for people who don’t drink. When they wake up in the morning, that’s as good as they’re going to feel all day.” (Frank Sinatra, Dean Martin, Jack Lemmon) Alcohol has always played a major role society; a substance at the centre of controversy since humanity’s beginning. It’s undeniable that its abuse has a negative impact in society, but it has a certain function in life outside of its identity as a vice and is tied to our nature (in moderation, of course). We recognize that it is here to stay, and as such have developed a product to provide relief and protection from all negative impacts. Dehydration, headaches, stomach pains; PROLIVERATE does not advocate alcohol abuse, but what it does do is help you feel better, and more importantly, be better.

 

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Description

Medicinal Ingredients
Medicinal Ingredients Per capsule Per 2 capsule(s)
LIVER SUPPORT COMPLEX
Turmeric Ext. (95% Curcuminoids; 10:1) 50.00mg 100.00mg
Amla Ext. (10:1) 100.00mg 200.00mg
Spirulina (Organic, Kosher) 100.00mg 200.00mg
RELIEF COMPLEX
Hovenia dulcis Ext. (98% Dihydromyricetin; 10:1) 100.00mg 200.00mg
Ginger Root Ext. (5% Gingerols; 20:1) 50.00mg 100.00mg
Prickly Pear Ext. (10:1) 50.00mg 100.00mg
Fruit Bromelain 50.00mg (900,000FCC PU) 100.00mg (1,800,000FCC PU)
ENERGY & HYDRATION MATRIX
Coconut Water Ext. (10:1) 50.00mg 100.00mg
Vitamin B1 (Thiamine) 10.00mg 20.00mg
Vitamin B2 (Riboflavin) 12.50mg 25.00mg
Vitamin B6 (Pyridoxine) 4.00mg 8.00mg
Quali®-D Vitamin D3 (Cholecalciferol) 10.00mcg (400IU) 20.00mcg (800IU)
ABSORPTION ENHANCER
Bioperine®Black Pepper Ext. (95% Piperine; 50:1) 5.00mg 10.00mg
Benefits
Liver Support Complex

Turmeric Rhizome Extract

  1. Main bioactive is curcumin and curcminoids
  2. One of the most potent anti-inflammatory agents (systemic, tested against osteoarthritis, oral inflammation, Diabetes, Ulcerative Colitis)1, 2
  3. Reduce liver enzyme levels, protection of liver damage noted clinically3, 4

Amla Extract

  1. Clinically validated benefits on cholesterol, blood triglyceride levels5, liver health (specifically against certain pharmaceuticals and toxins)6
  2. Rich bioactive of gallic acids, tannins, phytosterols, and vitamins providing an array of benefits

Spirulina

  1. Organic grade with 60% protein, high in B complex vitamins, Vitamin E, carotenoids, iron, manganese, zinc and essential fatty acids such as Gamma-linolenic acid (GLA)
  2. Increases plasma reduced glutathione levels post supplementation7

Relief Complex

Dihydromyricetin

  1. Naturally found in Hovenia dulcis (Japanese Raisin tree)
  2. Impact ethanol breakdown and blood alcohol content (attenuate ADH and ALDH enzyme activity)8,9
  3. Reduce inflammation and allergic response10
  4. Protect glucose homeostasis11, reducing effects of high caloric intake during drinking and heavy meals
  5. Combined with PROLIVERATE’s Non-GMO Apple Fiber, which is gel-forming, to deliver a sustained amount of nutrients12 to result in a prolonged protective effect of PROLIVERATE during a night out of drinking and eating.

Ginger Root Extract

  1. Concentrated extract of a wonder spice
  2. Delivers 65% total gingerols content, working to relieve your nausea13, 14
  3. Speed up gastric motility15, which relieves gas buildup and pressure in your digestive system

Prickly Pear Extract

  1. Studied specifically for its reduction of hangover symptoms – reduced nausea, dry mouth, and anorexia
  2. Risk of severe hangover and inflammatory response reduced by half16

Bromelain

  1. Arguably most powerful anti-inflammatory supplement ingredient (matching those of certain pharmaceuticals17)
  2. Naturally found in pineapples
  3. Mediate immune cells’ response to inflammatory signal, creating a state of anti-inflammation18,19, critical to preventing the source of many hangover symptoms
  4. As with all MAVERICK NUTRITION selected ingredients, dual purpose to increase bioavailability20,21 of nutrients and enhance PROLIVERATE’s liver and symptom relief ingredients.

Energy & Hydration Matrix

CocOganic™ Coconut Water Extract

  1. Certified -organic, freeze-dried coconut water extract sustainably sourced from the Philippines
  2. Naturally isotonic; contains similar profile of salts and sugars as in your body.
  3. Rich in electrolytes and trace minerals, helps maintain hydration status and pH balance

Vitamin B1

  1. Essential vitamin involved in glucose production
  2. During instances of high blood glucose (individuals with alcoholism or high carbohydrate intake), especially important to maintain proper energy maintenance and absorption of nutrients

Vitamin B2 i]

  1. Essential vitamin (required for proper Vitamin B6 utilization in your body)
  2. Major deficiency in individuals with alcoholism or high chronic intake of alcohol22,23
  3. A 25mg dose found to be an effective treatment for migraine frequencies24

Vitamin B6

  1. A coenzyme in more than 100 enzyme reactions in the metabolism of amino acids, glucose and lipids 25
  2. Found to be deficient in individuals with alcoholism or high chronic intake of alcohol

DSM Quali®-D Vitamin D3

  1. Higher doses of Vitamin D3 improve insulin sensitivity26,
  2. Found to be deficient in individuals with alcoholism or high chronic intake of alcohol27
References
  1. Khajehdehi, P., et al. “Oral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo-controlled study.” Journal of Renal Nutrition, vol. 22, no. 1, 2012, pp. 50-57., doi:10.1053/j.jrn.2011.03.002.
  2. Amalraj, A., et al. “A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study.” Journal of Medicinal Food, vol. 20, no. 10, 2017, pp. 1022–1030., doi:10.1089/jmf.2017.3930.
  3. Saadati, S. “The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver disease.” European Journal of Clinical Nutrition, vol. 73, no. 3, 2019, pp. 441-449., doi:10.1038/s41430-018-0382-9.
  4. Rahmani, S., et al. “Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial.” Phytotherapy Research, vol. 30, no. 9, 2016, pp. 1540–1548., doi:10.1002/ptr.5659.
  5. Bhatt, Jagatkumar, et al. “A Comparative Clinical Study of Hypolipidemic Efficacy of Amla (Emblica Officinalis) with 3-Hydroxy-3-Methylglutaryl-Coenzyme-A Reductase Inhibitor Simvastatin.” Indian Journal of Pharmacology, vol. 44, no. 2, 2012, p. 238., doi:10.4103/0253-7613.93857.
  6. Thilakchand, Karadka Ramdas, et al. “Hepatoprotective Properties of the Indian Gooseberry (Emblica Officinalis Gaertn): a Review.” Food & Function, vol. 4, no. 10, 2013, p. 1431., doi:10.1039/c3fo60237k.
  7. Kalafati, M., et al. “Ergogenic and antioxidant effects of spirulina supplementation in humans.” Medicine & Science in Sports & Exercise, vol. 42, no. 1, 2010, pp. 142-151., doi:10.1249/MSS.0b013e3181ac7a45.
  8. Sakai, Kiyoshi, et al. “Effect of Water Extracts of Crude Drugs in Decreasing Blood Ethanol Concentrations in Rats.” Chemical & Pharmaceutical Bulletin, vol. 35, no. 11, 1987, pp. 4597–4604., doi:10.1248/cpb.35.4597.
  9. Okuma, Yutaka, et al. “Effect of Extracts Form Hovenia Dulcis Thunb. on Alcohol Concentration in Rats and Men Administered Alcohol.” Nippon Eiyo Shokuryo Gakkaishi, vol. 48, no. 3, 1995, pp. 167–172., doi:10.4327/jsnfs.48.167.
  10. Wang, Rui, et al. “Dihydromyricetin Suppresses Inflammatory Responsesin Vitroandin Vivothrough Inhibition of IKKβ Activity in Macrophages.” Scanning, vol. 38, no. 6, 2016, pp. 901–912., doi:10.1002/sca.21339.
  11. Le, Liang, et al. “Metabolomics Reveals the Protective of Dihydromyricetin on Glucose Homeostasis by Enhancing Insulin Sensitivity.” Scientific Reports, vol. 6, no. 1, 2016, doi:10.1038/srep36184.
  12. Mcrorie, Johnson W. “Evidence-Based Approach to Fiber Supplements and Clinically Meaningful Health Benefits, Part 2.” Nutrition Today, vol. 50, no. 2, 2015, pp. 90–97., doi:10.1097/nt.0000000000000089.
  13. Mowrey, Danielb., and Dennise. Clayson. “Motion Sickness, Ginger, And Psychophysics.” The Lancet, vol. 319, no. 8273, 1982, pp. 655–657., doi:10.1016/s0140-6736(82)92205-x.
  14. Holtmann, S., et al. “The Anti-Motion Sickness Mechanism of Ginger: A Comparative Study with Placebo and Dimenhydrinate.” Acta Oto-Laryngologica, vol. 108, no. 3-4, 1989, pp. 168–174., doi:10.3109/00016488909125515.
  15. Wu, Keng-Liang, et al. “Effects of Ginger on Gastric Emptying and Motility in Healthy Humans.” European Journal of Gastroenterology & Hepatology, vol. 20, no. 5, 2008, pp. 436–440., doi:10.1097/meg.0b013e3282f4b224.
  16. Wiese, Jeff, et al. “Effect of Opuntia Ficus Indica on Symptoms of the Alcohol Hangover.” Archives of Internal Medicine, vol. 164, no. 12, 2004, p. 1334., doi:10.1001/archinte.164.12.1334.
  17. Wittenborg, Alfred, et al. “Vergleichende Epidemiologische Studie Bei Erkrankungen Des Rheumatischen Formenkreises Am Beispiel Der Therapie Mit Nichtsteroidalen Antiphlogistika versus Einem Oralen Enzymkombinationspräparat.” Arzneimittelforschung, vol. 50, no. 08, 2011, pp. 728–738., doi:10.1055/s-0031-1300280.
  18. Fitzhugh, David J., et al. “Bromelain Treatment Decreases Neutrophil Migration to Sites of Inflammation.” Clinical Immunology, vol. 128, no. 1, 2008, pp. 66–74., doi:10.1016/j.clim.2008.02.015.
  19. Hale, Laura P., et al. “Bromelain Treatment Alters Leukocyte Expression of Cell Surface Molecules Involved in Cellular Adhesion and Activation.” Clinical Immunology, vol. 104, no. 2, 2002, pp. 183–190., doi:10.1006/clim.2002.5254.
  20. Guggi, Davide, and Andreas Bernkop-Schnürch. “Improved Paracellular Uptake by the Combination of Different Types of Permeation Enhancers.” International Journal of Pharmaceutics, vol. 288, no. 1, 2005, pp. 141–150., doi:10.1016/j.ijpharm.2004.09.023.
  21. Grabovac, V., and A. Bernkop-Schnürch. “Improvement of the Intestinal Membrane Permeability of Low Molecular Weight Heparin by Complexation with Stem Bromelain.” International Journal of Pharmaceutics, vol. 326, no. 1-2, 2006, pp. 153–159., doi:10.1016/j.ijpharm.2006.06.042.
  22. Neville, Janice N., et al. “Nutritional Status of Alcoholics.” The American Journal of Clinical Nutrition, vol. 21, no. 11, 1968, pp. 1329–1340., doi:10.1093/ajcn/21.11.1329.
  23. Leevy, Carroll M., and Herman Baker. “Introduction.” The American Journal of Clinical Nutrition, vol. 21, no. 11, 1968, pp. 1325–1328., doi:10.1093/ajcn/21.11.1325.
  24. Maizels, Morris, et al. “A Combination of Riboflavin, Magnesium, and Feverfew for Migraine Prophylaxis: A Randomized Trial.” Headache: The Journal of Head and Face Pain, vol. 44, no. 9, 2004, pp. 885–890., doi:10.1111/j.1526-4610.2004.04170.x.
  25. “Vitamin B6.” Linus Pauling Institute, 2 Jan. 2019, lpi.oregonstate.edu/mic/vitamins/vitamin-B6.
  26. Sepehrmanesh, Zahra, et al. “Vitamin D Supplementation Affects the Beck Depression Inventory, Insulin Resistance, and Biomarkers of Oxidative Stress in Patients with Major Depressive Disorder: A Randomized, Controlled Clinical Trial.” The Journal of Nutrition, vol. 146, no. 2, 2015, pp. 243–248., doi:10.3945/jn.115.218883.
  27. Ogunsakin, Olalekan, et al. “Chronic Ethanol Exposure Effects on Vitamin D Levels among Subjects with Alcohol Use Disorder.” Environmental Health Insights, vol. 10, 2016, doi:10.4137/ehi.s40335.
Test Results
Assessment Criteria Test Test Method Specification Test Result
Identity Shape & Color Organoleptic
Performance Tests Disintegration USP <2040> ≤ 30 min @ 37°C & pH 4.5
Average Weight USP <2091> mg ± 10%
Weight Variation USP <2091> As Per USP
Purity/ Microbial contaminants Total Aerobic Count USP <2021> < 1 X 103 CFU/g
Total Combined Yeast and Mold USP <2021> < 1 X 102 CFU/g
Escherichia coli USP <2022> Absent
Salmonella spp. USP <2022> Absent
Staphylococcus aureus USP <2022> Absent
Heavy Metals Arsenic EPA/ICP/MS < 1.0ppm
Cadmium EPA/ICP/MS < 1.0ppm
Lead EPA/ICP/MS < 1.0ppm
Total Mercury EPA/ICP/MS < 1.0ppm

Additional information

Weight 0.0658 kg
Dimensions 8 × 5 × 1 cm
units

1 unit, 10 units