TRANQUILITY

$49.99

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In the ever-evolving world today, we are at the forefront of the human existence. In an age dominated by technological advances and leaps in scientific discovery, we have never been more enlightened by the world around us and never been more complex as a race. In this complexity, we are often troubled by various stressors in our ever-progressing lives. We recognize that sleep, stress, and mood are critically linked. Most commonly, synthetic melatonin is prescribed as the generic treatment for sleep. However, due to its negative long-term impacts and a whole range of adverse effects, better alternatives are needed. Through fortifying one’s defences against stress, promoting mood parameters, and improving sleep through both sedation and sleep quality augmentation, TRANQUILITY is the solution to balance out the scales, without synthetic melatonin.

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Description

Medicinal Ingredients
Medicinal Ingredients Per capsule Per 2 capsule(s)
ADAPTOGEN & MOOD ENHANCER
L-Tryptophan 110.00mg 220.00mg
Sensoril® Ashwagandha Ext. (45% Withania oligosaccharides, 20% Withanolide glycosides, 0.5% Withaferin A; 5:1) 62.50mg 125.00mg
Quali®-D Vitamin D3 (Cholecalciferol) 10.00mcg (400IU) 20.00mcg (800IU)
SEDATIVE COMPLEX
Chamomile Ext. (1% Apigenin; 20:1) 50.00mg 100.00mg
Lemon balm Ext. (20:1) 50.00mg 100.00mg
Tart Cherry Ext. (5% Anthocyanins; 30:1) 50.00mg 100.00mg
Passionflower Ext. (5% Flavonoids as hyperoside; 4:1) 50.00mg 100.00mg
RELAXATION & SLEEP OPTIMIZER
L-Theanine 100.00mg 200.00mg
Magnesium (Magnesium glycinate, Magnesium citrate) 75.00mg 150.00mg
Banaba Leaf Ext. (1% Corosolic acid; 4:1) 24.00mg 48.00mg
Benefits
Adaptogen & Mood Enhancer

Sensoril®Ashwagandha Extract

  1. Clinically verified (12 published studies) version of traditional Indian herb
  2. First extract to take advantage of bioactives across whole plant (normally just the root) using patented extraction process
  3. Reduces cortisol and C-reactive protein levels (stress indicator in body)1
  4. Improve sleep quality and mood parameters2
  5. Enhanced cognitive capacity and psychomotor performance during the day3

L-Tryptophan

  1. Important amino acid related to mood and sleep
  2. Precursor to serotonin, body’s happy molecule
  3. Validated by studies for calmative effect and neurotransmitter impact4,5
  4. Prescribed as mood enhancement drug for various mood disorders in high doses (bipolarism, depression)

Vitamin D3

  1. Vitamin D receptors in throughout human brain6
  2. Current evidence implicate low Vitamin D3 levels with increased likelihood of developing depression, suggesting Vitamin D3 as a viable preventative or beneficial therapy for depression7,8,9
  3. The Quali®-D has been used to ensure highest stability, bioavailability, and efficacy

Sedative Complex

Chamomile Extract

  1. Traditional medicine/food item with many bioactive compounds with wide range of beneficial properties (has been indicated traditionally for hay fever, inflammation, insomnia, rheumatic pain)
  2. Contains an important molecule, Apigenin, which binds to receptors in the brain and has been shown in preclinical studies to be a Central Nervous System (CNS) depressant and anticonvulsant10
  3. Strong evidence promoting Chamomile extract’s effects on individuals with generalized anxiety disorder11

Lemon balm Extract

  1. Dual function herb – cognitive benefit, stress reduction
  2. Known as a calmative, functions to impact GABA, impacting mood and sleep12
  3. Supplementation of lemon balm extract sedates and calms, but improves quality of memory in studies studying picture-recall, delayed word recall and spatial memory13

Tart Cherry Extract

  1. High natural melatonin profile
  2. Proposed mechanisms involved with increasing tryptophan availability to your body and reduced inflammation14
  3. Implicated in enhancing recovery during and post exercise, reducing inflammation and pain15

Passionflower Extract

  1. Established traditional sleep remedy
  2. Validated in human and animal studies for Generalized Anxiety Disorder as an anticonvulsant with anxiolytic effects, and modulates circadian rhythm16,17,18,19

Relaxation & Sleep Optimizer

L-Theanine

  1. Not common in modern diet
  2. Structurally similar to glutamine and related neurotransmitters
  3. Can cross blood brain barrier, and can reduce self-reported stress levels and improve attention without being a stimulant (i.e. caffeine)20,21

Magnesium (bisglycinate, oxide)

  1. Important mineral in which deficiencies are linked to many sleep and anxiety disorders
  2. 2019 meta-analysis found ADHD afflicted children had significantly reduced levels of magnesium22
  3. Potent cortisol reducer with “possible efficacy…as a mood stabilizer”23
  4. High bioavailable form of magnesium, which ahs a glycinegroup that buffers against intestinal pH and increases solubility of magnesium, protecting magnesium from inhibitory substances.

Banaba Leaf Extract

  1. Anti-diabetic herb with impacts on carbohydrate intake and absorption
  2. As much as 20-30% blood glucose reduction according to studies, significantly higher than any other supplement24
  3. High blood sugar levels after dinner will negatively impact sleep and subsequent energy levels during the day
References
  1. Auddy, Biswajit & Hazra, Jayram & Mitra, Achintya & Abedon, Bruce & Ghosal, Shibnath. (2008). A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study. Journal of American Nutraceutical Association. 11. 50-56.
  2. Pingali, Usharani, et al. “Effect of Standardized Aqueous Extract of Withania Somniferaon Tests of Cognitive and Psychomotor Performance in Healthy Human Participants.” Pharmacognosy Research, vol. 6, no. 1, 2014, p. 12., doi:10.4103/0974-8490.122912.
  3. Pingali, Usharani, et al. “Effect of Standardized Aqueous Extract of Withania Somniferaon Tests of Cognitive and Psychomotor Performance in Healthy Human Participants.” Pharmacognosy Research, vol. 6, no. 1, 2014, p. 12., doi:10.4103/0974-8490.122912.
  4. Jenkins, Trisha, et al. “Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis.” Nutrients, vol. 8, no. 1, 2016, p. 56., doi:10.3390/nu8010056.
  5. Winokur, Andrew, et al. “Hormonal and Behavioral Effects Associated with Intravenousl-Tryptophan Administration.” Psychopharmacology, vol. 88, no. 2, 1986, pp. 213–219., doi:10.1007/bf00652243.
  6. Eyles, Darryl W, et al. “Distribution of the Vitamin D Receptor and 1 Alpha-Hydroxylase in Human Brain.” Journal of Chemical Neuroanatomy, U.S. National Library of Medicine, Jan. 2005, www.ncbi.nlm.nih.gov/pubmed/15589699.
  7. Kjærgaard, Marie, et al. “Effect of Vitamin D Supplement on Depression Scores in People with Low Levels of Serum 25-Hydroxyvitamin D: Nested Case—Control Study and Randomised Clinical Trial.” British Journal of Psychiatry, vol. 201, no. 05, 2012, pp. 360–368., doi:10.1192/bjp.bp.111.104349.
  8. Jääskeläinen, Tuija, et al. “Higher Serum 25-Hydroxyvitamin D Concentrations Are Related to a Reduced Risk of Depression.” British Journal of Nutrition, vol. 113, no. 09, 2015, pp. 1418–1426., doi:10.1017/s0007114515000689.
  9. Grudet, Cécile, et al. “Suicidal Patients Are Deficient in Vitamin D, Associated with a pro-Inflammatory Status in the Blood.” Psychoneuroendocrinology, vol. 50, 2014, pp. 210–219., doi:10.1016/j.psyneuen.2014.08.016.
  10. Viola, H., et al. “Apigenin, a Component OfMatricaria RecutitaFlowers, Is a Central Benzodiazepine Receptors-Ligand with Anxiolytic Effects.” Planta Medica, vol. 61, no. 03, 1995, pp. 213–216., doi:10.1055/s-2006-958058.
  11. Awad, R., et al. “Effects of Traditionally Used Anxiolytic Botanicals on Enzymes of the γ-Aminobutyric Acid (GABA) SystemThis Article Is One of a Selection of Papers Published in This Special Issue (Part 1 of 2) on the Safety and Efficacy of Natural Health Products.” Canadian Journal of Physiology and Pharmacology, vol. 85, no. 9, 2007, pp. 933–942., doi:10.1139/y07-083.
  12. Kennedy, David O., et al. “Attenuation of Laboratory-Induced Stress in Humans After Acute Administration of Melissa Officinalis (Lemon Balm).” Psychosomatic Medicine, vol. 66, no. 4, 2004, pp. 607–613., doi:10.1097/01.psy.0000132877.72833.71.
  13. Scholey, Andrew, et al. “Anti-Stress Effects of Lemon Balm-Containing Foods.” Nutrients, vol. 6, no. 11, 2014, pp. 4805–4821., doi:10.3390/nu6114805.
  14. Losso, Jack N., et al. “Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms.” American Journal of Therapeutics, vol. 25, no. 2, 2018, doi:10.1097/mjt.0000000000000584.
  15. Kuehl, Kerry S, et al. “Efficacy of Tart Cherry Juice in Reducing Muscle Pain during Running: a Randomized Controlled Trial.” Journal of the International Society of Sports Nutrition, vol. 7, no. 1, 2010, doi:10.1186/1550-2783-7-17.
  16. Guerrero, Fructuoso Ayala, and Graciela Mexicano Medina. “Effect of a Medicinal Plant (Passiflora Incarnata L) on Sleep.” Sleep Science, vol. 10, no. 3, 2017, pp. 96–100., doi:10.5935/1984-0063.20170018.
  17. Akhondzadeh, S., et al. “Passionflower in the Treatment of Generalized Anxiety: a Pilot Double-Blind Randomized Controlled Trial with Oxazepam.” Journal of Clinical Pharmacy and Therapeutics, vol. 26, no. 5, 2001, pp. 363–367., doi:10.1046/j.1365-2710.2001.00367.x.
  18. Jawna-Zboińska, Katarzyna, et al. “Passiflora IncarnataL. Improves Spatial Memory, Reduces Stress, and Affects Neurotransmission in Rats.” Phytotherapy Research, vol. 30, no. 5, 2016, pp. 781–789., doi:10.1002/ptr.5578.
  19. Kazuya, Toda, et al. “Passionflwoer Extract Induces High-amplitude Rhythms without Phase Shifts in the Expression of Several Circadian Clock Genes in Vitro and in Vivo.” Int Journal of Biomedical Science, vol. 13(2), 2017, pp. 84-92, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542920.
  20. Higashiyama, Akiko, et al. “Effects of l-Theanine on Attention and Reaction Time Response.” Journal of Functional Foods, vol. 3, no. 3, 2011, pp. 171–178., doi:10.1016/j.jff.2011.03.009.
  21. White, David, et al. “Anti-Stress, Behavioural and Magnetoencephalography Effects of an l-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.” Nutrients, vol. 8, no. 1, 2016, p. 53., doi:10.3390/nu8010053.
  22. Huang, Yu-Hui, et al. “Significantly Lower Serum and Hair Magnesium Levels in Children with Attention Deficit Hyperactivity Disorder than Controls: A Systematic Review and Meta-Analysis.” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 90, 2019, pp. 134–141., doi:10.1016/j.pnpbp.2018.11.012.
  23. Held, K., et al. “Oral Mg2+ Supplementation Reverses Age-Related Neuroendocrine and Sleep EEG Changes in Humans.” Pharmacopsychiatry, vol. 35, no. 4, 2002, pp. 135–143., doi:10.1055/s-2002-33195.
  24. Judy, William V., et al. “Antidiabetic Activity of a Standardized Extract (Glucosol™) from Lagerstroemia Speciosa Leaves in Type II Diabetics.” Journal of Ethnopharmacology, vol. 87, no. 1, 2003, pp. 115–117., doi:10.1016/s0378-8741(03)00122-3.
Test Results
Assessment Criteria Test Test Method Specification Test Result
Identity Shape & Color Organoleptic
Performance Tests Disintegration USP <2040> ≤ 30 min @ 37°C & pH 4.5
Average Weight USP <2091> mg ± 10%
Weight Variation USP <2091> As Per USP
Purity/ Microbial contaminants Total Aerobic Count USP <2021> < 1 X 103 CFU/g
Total Combined Yeast and Mold USP <2021> < 1 X 102 CFU/g
Escherichia coli USP <2022> Absent
Salmonella spp. USP <2022> Absent
Staphylococcus aureus USP <2022> Absent
Heavy Metals Arsenic EPA/ICP/MS < 1.0ppm
Cadmium EPA/ICP/MS < 1.0ppm
Lead EPA/ICP/MS < 1.0ppm
Total Mercury EPA/ICP/MS < 1.0ppm

Additional information

Weight 0.1058 kg
Dimensions 6 × 6 × 12 cm